Singapore Radiopharmaceuticals Pte Ltd (SRP) is a comprehensive radiopharmaceutical production facility providing advance radiopharmaceuticals for PET (positron-emission tomography) and SPECT (single-photon emission tomography) for Oncology, Nuclear Cardiology, Neurology, Neuropsychiatry, Infection Imaging and various other diseases. SRP provide services to academia to investigate the physiology and imaging (detection/quantification) of disease. Through seamless collaboration with industry and academic partners, SRP can support organizations engaged in New Drug Discovery and Development to accelerate preclinical and clinical drug programs. Specifically, radio analogues of new drugs can be made to evaluate their in-vivo pharmacokinetic profile or transport across the blood brain barrier, bio-distribution or ability to target biomarkers and efficacy.
Radiopharmaceuticals
GMP Production
Based around a Central Nuclear Pharmacy operated to GMP standards, we produce the broadest range of radiopharmaceuticals for both pre-clinical and clinical use at PET centers in Singapore.
| Tracers produced | Indications |
|---|---|
| 18F-FDG | Targets Glucose Metabolism |
| 68Ga-PSMA | Targets Prostate Cancer |
| 68Ga-DOTA-TATE, 68Ga-DOTA-NOC, 68Ga-DOTA-TOC | Targets Neuroendocrine Tumours |
| 11C-Acetate | Targets Liver Cancer |
| 18F-Flutemetamol | Targets for Alzheimer’s Disease |
| 18F-Choline | Targets Hypoxic Tumours |
| 18F-Sodium Fluoride | Targets Bone Cancer |
| 18F-Fluorothymidine | Targets Cancer Cell Proliferation |
| 18F-PE2I | Targets Parkinson’s Disease |
| 18F-MISO | Targets Tumour Cell Hypoxia |
| 11C-Raclopride | Targets Parkinson’s Disease |
| 11C-Methionine | Targets Brain Cancer |
| 11C-PBR28 | Targets Brain Inflammation |
Custom Radiolabeling
In-house expertise is available to provide custom radiolabeling of small and large molecules, including peptides and antibodies using isotopes including Iodine-124 and Zirconium-89. In addition, expertise in regulatory aspects and GMP manufacture of tracers provides pharmaceuticals companies with a compliant site to produce new proprietary tracers for evaluation in clinical trials or to manufacture for sale.
Facility Lease and Equipment Hire
Facility and equipment hire is available including training workshops and consultancy services for Medical Physics and Radiation Protection, GMP etc.
Consultation and Partnership
SRP has established relationship and collaborations with institutions such as NTU and A-Star. SRP also partners Nuclear Medicine Physicians in both the public and private sector to write grants investigating advanced imaging tracers aimed at early identification of common cancers in Singapore.
