Singapore Radiopharmaceuticals Pte Ltd (SRP) is a comprehensive radiopharmaceutical production facility providing advance radiopharmaceuticals for PET (positron-emission tomography) and SPECT (single-photon emission tomography) for Oncology, Nuclear Cardiology, Neurology, Neuropsychiatry, Infection Imaging and various other diseases.
Operational since 2008 SRP is the only cyclotron in Singapore capable of producing the isotopes Carbon-11 and Fluorine-18. In addition, the isotopes Lutetium-177, Actinium-225, Iodine-124, Zirconium-89. Copper-64, and Gallium-68 are also available. Providing the most comprehensive range of clinical radiopharmaceuticals in the region to PET centres throughout Singapore. Currently more than 10 tracers are available to investigate diseases especially different forms of Cancer.
SRP provide services to academia to investigate the physiology and imaging (detection/quantification) of disease. Through seamless collaboration with industry and academic partners, SRP can support organizations engaged in New Drug Discovery and Development to accelerate preclinical and clinical drug programs. Specifically, radio analogues of new drugs can be made to evaluate their in-vivo pharmacokinetic profile or transport across the blood brain barrier, bio-distribution or ability to target biomarkers and efficacy.
Molecular Imaging (MI) is a method of visualizing processes within cells.
A PET-CT scanner is used along with special drugs called radiopharmaceuticals that emit a signal from within the cell, to create an image of the specific intracellular process of interest.
The doctor can establish quickly disease occurrence, response to therapy, progression and reoccurrence using PET-CT scans.
SRP provides the most comprehensive set of tracers to physicians in hospitals throughout Singapore.
SRP has established new tracers in Singapore used in preclinical research to investigate biomarkers of disease and response to therapy.
Various peptides and antibodies have been labelled with long half isotopes to look at drug bio-distribution and in-vivo pharmacokinetics.
SRP has directly supported clinical trials using advanced tracers to examine response to therapy of new drugs aimed and reducing tumour volume.
Recent work includes conjugation (DFO, MECOSar, COSar), purification and radiolabelling of new engineered antibody fragments, minibodies and peptides with Cobalt-57 and Zirconium-89.
Based around a Central Nuclear Pharmacy operated to GMP standards, we produce the broadest range of radiopharmaceuticals for both pre-clinical and clinical use at PET centres in Singapore.
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TRACERS PRODUCED |
INDICATIONS |
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18F-FDG |
Targets Glucose Metabolism |
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68Ga-PSMA |
Targets Prostate Cancer |
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68Ga-DOTA-TATE, 68Ga-DOTA-NOC, 68Ga-DOTA-TOC |
Targets Neuroendocrine Tumours |
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11C-Acetate |
Targets Liver Cancer |
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18F-Flutemetamol (Vizamyl) |
Targets for Alzheimer’s Disease |
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18F-PSMA |
Targets Prostate Cancer |
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18F-Choline |
Targets primary prostate cancer |
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18F-Sodium Fluoride |
Targets Bone Cancer |
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18F-Fluorothymidine |
Targets Cancer Cell Proliferation |
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18F-PE2I |
Targets Brain Cancer |
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18F-MISO |
Targets Tumour Cell Hypoxia |
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11C-Raclopride |
Targets Parkinson’s Disease |
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11C-Methionine |
Targets Brain Cancer |
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11C-PBR28 |
Targets Brain Inflammation |
In-house expertise is available to provide custom radiolabelling of small and large molecules, including peptides and antibodies using isotopes including Lutetium-177, Actinium-225, Iodine-124, Zirconium-89. Copper-64, and Gallium-68.
In addition, expertise in regulatory aspects and GMP manufacture of tracers provides pharmaceuticals companies with a compliant site to produce new proprietary tracers for evaluation in clinical trials or to manufacture for sale.
Facility and equipment hire is available including training workshops and consultancy services for Medical Physics and Radiation Protection, GMP etc.
SRP has established relationship and collaborations with institutions such as NTU and A-Star.
SRP also partners Nuclear Medicine Physicians in both the public and private sector to write grants investigating advanced imaging tracers aimed at early identification of common cancers in Singapore.
Monday - Friday: 8:30AM – 5:30PM
Saturday: 8:30AM – 12:30PM
Closed on Sundays and Public Holidays
Monday – Friday: 8:30AM – 5:00PM (Lunch hour: 1:00PM – 2:00PM)
Saturday: 8:30AM – 1:00PM
